LP-IR Calculator - Lipoprotein Insulin Resistance Score

LP-IR Score Formula:

\[ LPIR = f(HDL\_P, LDL\_P, VLDL\_P, HDL\_Size, LDL\_Size, VLDL\_Size) \]

HDL-P (μmol/L):

LDL-P (nmol/L):

VLDL-P (nmol/L):

HDL Size (nm):

LDL Size (nm):

VLDL Size (nm):

LP-IR Score (0-100):

Interpretation:

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1. What is LP-IR Score?

Definition: LP-IR (Lipoprotein Insulin Resistance) is a composite score (0-100) derived from NMR-measured lipoprotein parameters that reflects insulin resistance status.

Purpose: It provides an early indicator of insulin resistance and diabetes risk before glucose abnormalities appear.

2. How Does LP-IR Work?

The score is calculated using six NMR-measured lipoprotein parameters:

\[ LPIR = f(HDL\_P, LDL\_P, VLDL\_P, HDL\_Size, LDL\_Size, VLDL\_Size) \]

Where:

HDL-P — HDL particle concentration (μmol/L)
LDL-P — LDL particle concentration (nmol/L)
VLDL-P — VLDL particle concentration (nmol/L)
HDL Size — Average HDL particle size (nm)
LDL Size — Average LDL particle size (nm)
VLDL Size — Average VLDL particle size (nm)

Note: The exact algorithm is proprietary to LabCorp. This calculator provides an approximation.

3. Clinical Importance of LP-IR

Details: Higher LP-IR scores correlate with greater insulin resistance and predict development of type 2 diabetes.

4. Using the Calculator

Tips: Enter all six lipoprotein parameters from NMR testing. Values must be > 0.

5. Frequently Asked Questions (FAQ)

Q1: What's a normal LP-IR score?
A: Scores below 45 suggest low insulin resistance, 45-60 moderate, and above 60 high resistance.

Q2: How accurate is this calculator?
A: This provides an approximation. The exact LP-IR algorithm is proprietary to LabCorp.

Q3: Where can I get these lipoprotein measurements?
A: NMR lipoprotein testing is available through specialized labs like LabCorp and Quest.

Q4: Can LP-IR change over time?
A: Yes, with lifestyle changes, weight loss, or medications that improve insulin sensitivity.

Q5: How does LP-IR compare to HOMA-IR?
A: LP-IR detects insulin resistance earlier than HOMA-IR and doesn't require fasting insulin.